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People with cancer, particularly blood cancer, are at increased risk of Stevens-Johnson syndrome. The immune system can be affected by an organ transplant, HIV/AIDS and autoimmune diseases. Among people with HIV, the incidence of Stevens-Johnson syndrome is about 100 times greater than among the general population.

Risk factorsįactors that increase your risk of developing Stevens-Johnson syndrome include: Infections that can cause Stevens-Johnson syndrome include pneumonia and HIV.

Pain relievers, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).

Antibacterial sulfonamides (including sulfasalazine).

Medications to treat seizures and mental illness (anticonvulsants and antipsychotics).

Anti-gout medications, such as allopurinol.

You may react to medication while you're using it or up to two weeks after you've stopped using it.ĭrugs that can cause Stevens-Johnson syndrome include:

Your health care provider may not be able to identify its exact cause, but usually the condition is triggered by medication, an infection or both. Stevens-Johnson syndrome is a rare and unpredictable illness.